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杨侃

更新时间:2021-03-26 15:59:39点击次数:

个人介绍:

杨侃,男,博士,讲师,硕士生导师。2012年毕业于沈阳药科大学,获得学士学位。2018年毕业于中国药科大学,获得药物化学博士学位。目前从事药物分子设计、合成与优化工作,开发新型抗肿瘤及治疗肺动脉高压等疾病的药物。同时利用计算机辅助药物设计技术,开展分子模拟研究。近年来主持国家自然科学、河北省自然科学基金等多项课题。目前已在J. Med. Chem, Eur. J. Med. Chem., Future Med. Chem. 等国际学术刊物发表多篇SCI论文,申请发明专利8项,其中授权3项。


主讲课程

药物化学、高等药物化学、药物设计学、波谱解析、药物合成反应


主要研究方向:

药物分子设计与合成研究:针对体内鞘脂信号通路的关键酶,如鞘氨醇激酶1/2、鞘磷脂酶、神经酰胺酶等,利用药物设计技术,开展新型酶抑制剂的设计与合成研究,通过小分子抑制剂调控各类鞘脂的水平,探索对肿瘤、动脉粥样硬化、肺动脉高压等疾病的影响及基于该通路进行药物开发的潜力。


药物与靶标分子模拟研究:针对潜在的药用靶标,开展建模、分子对接及动力学模拟等研究,探索蛋白与底物和抑制剂的结合机制及作用模式,并进行抑制剂筛选研究。


主要研究项目:

1. 国家自然科学基金委,青年项目,82003597,新型鞘氨醇激酶-1抑制剂的设计、合成与抗肺动脉高压活性研究,2021-012023-1224万元,在研,主持

2. 河北省自然科学基金委员会,生物医药联合项目,H2022201041,基于天然产物Jaspine B的鞘氨醇激酶抑制剂的设计、合成与抗肿瘤活性研究,2022.1-2024.1215万元,在研,主持

3. 国家自然科学基金面上项目,基于PD-L1降解的DHHC3抑制剂设计合成及抗肿瘤免疫活性研究(82273792),2023.01--2026.12,在研,51万元,参与。

4. 河北省教育厅,河北省高等学校科学技术研究项目青年项目,QN2022057,共价可逆型棕榈酰基转移酶-1抑制剂的开发与抗肿瘤免疫活性研究,2022.12024.123万元,在研,主持

5. 河北省自然科学基金委员会,青年项目,B2019201359,基于鞘氨醇激酶2鞘脂变阻器调控剂的设计、合成与抗肿瘤活性研究,2019-012021-126万元,结题,主持

6. 国家自然科学基金委,面上项目,82073710酸性鞘磷脂酶直接抑制剂的设计、合成及其抗抑郁的作用和机制研究,2021-012024-1255万元,在研,参加


联系方式:yangkan1014@hbu.edu.cn


发表论文:

1. Yang Kan, Nong Keyi, Xu Fei, Chen Yu, Yu Jinying, Lin Lizhi, Hu Xiao, Wang Youzhi, Li Ting, Dong Jibin*, Wang Jinxin*. Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis. J Med Chem. 2023, 66(4): 2681-2698. SCI

2. Tian Gao, Shuya Liu, Xiaocun Li, Zichen Qin, Kaiyue Wang, Jinxin Wang, Yali Song*, Kan Yang*, Recent progress of palmitoyl transferase DHHC3 as a novel antitumor target, Future Med. Chem., 2022, 14(6): 443-455SCI

3. Shang YanGuo, Wang Minghui, Hao Qingjing, Meng Tao, Li Lili, Shi Junwei, Yang Guoqing, Zhang Zhilan, Yang Kan*, Wang Jinxin*. Development of indole-2-carbonyl piperazine urea derivatives as selective FAAH inhibitors for efficient treatment of depression and pain. Bioorg Chem. 2022, 128:106031SCI

4. Kan Yang, Jinying Yu, Keyi Nong, Youzhi Wang, Ao Niu, Wenlu Chen, Jibin Dong, Jinxin Wang, Discovery of potent, selective, and direct acid sphingomyelinase inhibitors with antidepressant activity, J. Med. Chem. 2020, 63, 961-974 SCI

5. Jinmiao Zhang, Maoyu Zhang, Jinying Yu, Yanguo Shang, Kaixuan Jiang, Yihe Jia, Jinxin Wang*, Kan Yang*, Investigating the binding mechanism of sphingosine kinase 1/2 inhibitors: Insights into subtype selectivity by homology modeling, molecular dynamics simulation and free energy calculation studies, J. Mol. Struct, 2020, 1208: 127900 SCI

6. Zhang Jinmiao, Hao Qingjing, Jiang Kaixuan, Li Lili, Zhang Maoyu, Wang Jinxin*, Yang Kan*, Advances in understanding the role of sphingosine kinase-2 in tumorigenesis and its inhibitors, Acta Pharmaceutica Sinica 2020, 55(9): 2062 −2069

7. Kan Yang#*, Kaixuan Jiang, Zhengwen Xu, Yali Song, Jinxin WangTargeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertensionFuture Med. Chem. 2019, 11(22): 2939-2953 SCI

8. Kan Yang, Keyi Nong, Qinlan Gu, Jibin Dong, Jinxin Wang, Discovery of N-hydroxy-3-alkoxybenzamides as direct acid sphingomyelinase inhibitors using a ligand-based pharmacophore model, Eur. J. Med. Chem., 2018, 151: 389-400SCI

9. Kan Yang, Biao Gao, Xianjun Ming, Zhipeng Huang, Minghui Wang, Jibin Dong, Jinxin Wang, Design, synthesis, biological evaluation and QSAR analysis of 1, 3, 6, 7, 8-substituted xanthones as novel acid sphingomyelinase inhibitors: potential treatment for ultraviolet-induced skin damage, Future Med. Chem., 2017, 9(16): 1887-1898. SCI

10. Kan Yang, Kuojun Zhang, Songyuan Hu, Qinlan Gu, Jibin Dong*, Jinxin Wang*, Design, Synthesis and Biological Activity of Acid Sphingomyelinase Inhibitors, Chem. J. Chin. Univ., 2015, 36: 279-286SCI

11. Kuojun Zhang, Qinlan Gu, Kan Yang, Xianjun Ming, Jinxin Wang*, Anticarcinogenic Effects of a-Mangostin: A Review, Planta. Med., 2017, 83(3-04): 188-202SCI

12. Xianjun Ming, Kan Yang, Biao Gao, Qinlan Gu and Jinxin Wang*. Recent Progress in the Functionalization of Benzo-γ-Pyrones via Transition-Metal Catalyzed Cross-Coupling Reactions [J]. Mini-Reviews in Organic Chemistry, 2016, 13(1): 31-48SCI

13. Kuojun Zhang, Qinlan Gu, Minghui Wang, Li Zhao, Kan Yang, Jinxin Wang*, Research Progress in Acidic Sphingomyelinase/Ceramide Pathway: Its Role and Mechanism in Development of Related Diseases, Prog. Pharm. Sci., 2015, 39(11): 838-845


发明专利:

1. 杨侃,张金淼,曹飞,李龙飞,宋亚丽,五元杂环取代的苯甲酰胺类化合物及其制备方法与应用,CN202210044554.6

2. 杨侃,李港,张金淼,李龙飞,曹飞,宋亚丽,间二苯酚醚类化合物及其制备方法与应用,CN202210043149.2



(编辑:科研科)